COLLOIDAL BISMUTH SUBCITRATE (C.B.S) TABLETS
Bismuth salts have been used in medicine for over three centuries, particularly in the treatment of dyspepsia. Commonly used agents include Colloidal Bismuth Subcitrate (C.B.S.), Bismuth Subsalicylate (BSS) & the newer Ranitidine Bismuth Citrate (RBC). These are safe drugs which exert local effect on the gastroduodenal mucosa.
Colloidal Bismuth Subcitrate (C.B.S.) is a mineral that is used in treating ulcers and upset stomach.
It causes an increase in mucus glycoprotein
secretion and may also bind to the gastric
mucus layer to act as a diffusion barrier to HCl.
CBS accelerates ulcer healing and causes an
accumulation of epidermal growth factor around
the ulcer. In addition, it has a cytoprotective
effect and increases mucosal secretion of
prostaglandins and bicarbonate. CBS has
bactericidal effects against Helicobacter pylori
(which is associated with gastritis and peptic
ulcers). It also prevents adhesion of H. pylori to
epithelial cells and can inhibit enzymes secreted
by H. pylori, such as proteases, lipases,
glycosidases, and phospholipases.
AMBIS - 120